Protein Details: Aquaporin-4

Protein ID

ICDB_Pro_0137

Protein Name

Aquaporin-4

Gene Name

AQP4

Organism

Milnesium tardigradum (Water bear) (Tardigrade)

Length

349 amino acids

AlphaFoldDB

AF-G5CTG1-F1-model_v4.pdb

Function

Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.

Sequence

MSKVPPTDPFSHMLNGNLQQRIVKRDIDGEVPTERAVTDLASEKAHAIATHGEVVIQIQHSDTFGMDKEKNDWRSRAARMLYIESRLVREGLSESLAMFFFMSLLLGCAATARFTGNQNDPMLAAFYHGFSIIFAIYVAGGISGGLLNPAITFTIAFLGRLSWLRCLIYMSAQYFGAFIASAVVYLIYYDSLQNFSGANKVDETGANGTAGIWSTFPRPYLSLRGAIFNQIFCTMLLTIGFLSICDFRNSRPDKGMFPFAVGMLIMTVFLAFSYSAGAAMNPARDISPRLWTLIVGYGDEVFSYNNYKWFWIPWLFPYVGALLGGVIYEIFIGIHWPKDYANKHVTNRT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.4137/bbi.s11497; 10.1371/journal.pone.0045682